The current coronavirus disease 19 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and its variants. Though various vaccines are now available in the market and become effective in reducing the severity of disease and hospitalization, still for those who are infected with SARS-CoV-2 there is no effective treatment to deal with this health emergency, and therefore, there is an urgent need for the new treatments. The design of new therapies must be focused not only on the elimination of the virus but also on the recovery of the affected lung tissue and the avoidance or
reduction of the severe sequels. In that sense, treatments based on regenerative medicine and specifically platelet-rich plasma (PRP) could be found suitable and effective to tackle this disease.
Lyophilized PRP in nebulized form can be effective as it directly enters the lungs and unique properties of PRP such as immunomodulatory, anti-inflammatory, angiogenic, anti-fibrotic and antiapoptotic, anti-bacterial properties as well as stimulation of different cells, etc.
exerts their effect to improve the health condition rapidly. However, further
studies are warranted to prove its efficacy. In this review, we used words like
COVID-19, drugs used in the nebulized form in COVID-19, platelets, the role of
platelets in various disease conditions, platelet-rich plasma, nebulization,
lyophilization for selecting, extracting, and synthesizing data using Google search
engine, PubMed search. This review is focused on the advantages and
applications of LPRP in nebulized form as a treatment in COVID-19 patients
How Is It Done ?
- GrowthTested for cell morphology, proliferation potential, adherence rate, and viability
- Trilineage differentiationEach lot of stem cells is tested to ensure invitro differentiation of osteogenic, adipogenic and chondrogenic lineages
- Sterility TestingBacteria, Yeast, Fungi and Mycoplasma
- Viral Testing Hepatitis B, Hepatitis C, HIV
- Specific StainingAnalysed for cell surface markers by Flow Cytometry
Applications
- Adult stem cell differentiation into adipogenic,osteogenic and chondrogenic and lineages
- Regenerative medicine,
- Cell therapy,
- Tissue engineering,
- Generation of iPS cell lines
- In-vitro model for studying disease mechanism, drug discovery
- Wound healing
- Anti-ageing
- In-Vitro screening of immunomodulatory drugs
- Vaccine development, HIV research
Ethical Regulations & Guidelines
All the human stem cells supplied by StemRx are isolated from tissues ethically obtained from donors after getting consent form. Donors are rigorously screened for viral and bacterial markers to ensure the absence of HIV virus, Hepatitis B virus, Hepatitis C virus, Cytomegalovirus, Human T-lymphotropic virus, malarial parasites and syphilis to meet the product safety standards. The Institutional ethics committee (IEC) at StemRx Biosciences Pvt Ltd have approved all procedures related to human stem cells.
Manufacturing License
StemRx is the only manufacturer of Bone marrow derived cells in India. We have the manufacturing license to produce: mononuclear cells, natural killer cells, PRP, Mesenchymal stem cells that include Bone marrow derived cells, adipose derived cells, cord blood cells, umbilical cord cells, placenta derived cells, amniotic fluid derived cells
WHO-GMP Compliant Facility
Manufacturing in its own GMP compliant facilities (class 1000)
Cryopreserved at Primary Passage
Each batch of primary cells and stem cells are cryopreserved at passage number one using controlled rate freezer to warrant high viability and functionality of the cells
Reproducibility
Numerous vials of a single lot can be offered upon request which allows researchers to use the same cells for entire experiment
Flexibility
Cells are available in proliferating form in flasks as well as cryopreserved form in vials
The Process
